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Ran offers to donate blood to Conan, after he is shot earlier in the arc, without stopping to check his blood type, implying she knows he is Shinichi. Conan's blood type is a major plot point during the Desperate Revival arc.In the end, the best he can say is that at least he saved a life - until Black Jack gives him a check for most of the money he initially paid him. In order to help him, the businessman misses a vital plane flight and winds up losing his entire company. Several months later, the construction worker is himself injured. When he desperately needs a transfusion after an accident, he pays Black Jack a significant sum of money for help, and a construction worker is found who matches him. One story in Black Jack features a rich businessman with a rare blood type.She refused, so instead, Deimos made a deal with the friend: He healed her face but in turn she would need AB-Negative blood of young girls to keep her face from rotting. In the '70s Shoujo horror/romance manga Akuma no Hanayome ( Bride of Deimos), there's a story in the manga about the main character Minako's friend who was horribly disfigured in a car accident and Deimos offered a deal to Minako, that he would fix her friend's face if she agreed to marry him.The most difficult type to match is actually O-, since the same factors that make O- the universal donor also mean that O- patients are only compatible with O- blood note and O- being the universal donor can also reduce the availability of this type, given that it's the go-to for emergency situations where blood type is unknown and is also a fallback for all blood types when other compatible matches run out, while every other blood type is compatible with at least itself and O- however, O- blood is also not as rare as AB-, appearing in just under 7% of the population, so the chances of having some available or finding a donor are better. When it comes to compatible matches, AB- blood is actually not that hard to match, because an AB- patient can receive transfusions of any Rh negative blood type (A-, B-, AB-, or O-), which are found in about 15% of the population. This is also how James Harrison became "The Man with the Golden Arms". note In a sufficiently critical situation, such as when a patient is literally going through dozens or hundreds of units, even incompatible blood can be used, with compatible units reserved for the first few and last few transfusions all the problems that would normally result from transfusing a type O patient with type A blood are negated when the patient's own blood is long gone and the type A blood is hemorrhaged out almost immediately. In reality, while doctors do prefer to match blood type exactly when possible (especially when doing organ transplants, to reduce the risk of rejection), in a life-or-death situation - which is the only situation this trope would find worthwhile - any compatible blood type will do.
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Because AB- is the rarest blood type (found in less than 1% of the population), cases of the latter will often give the character an AB- blood type. Blood in fiction really comes in only two types: universal donor (O-, rare) and special needs (common), so that blood banks are overtaxed whenever the plot requires. Although most of the real world gets by quite peacefully with the more common blood types, in the world of entertainment only the rarest will do if a character's blood type is mentioned, you can bet that it's going to be rare and special.